Publications | Haridasbrode

Selectfluor Mediated Regioselective Annulation Using Imidazopyridines, Acetophenones and DMF as Carbon Synthon

Saradhi Kalari, Vijaya Rani Potluri, Dnyaneshwar J. Choudhari, Sridhar Balasubramanian, Haridas B. Rode

Advanced Synthesis and Catalysis, 2023.

Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process

Chennam Ramu, T. Kumaraguru, M. Sridhar Reddy, Haridas B. Rode, Subhash Ghosh, Ch. Raji Reddy , Gangarajula Sudhakar

Synthesis, 2023, 55, A–H.

Iron mediated reductive cyclization/oxidation for the generation of chemically diverse scaffolds: An approach in drug discovery

Uttam B. Karale, Akash Shinde, Vikas R. Gaikwad, Saradhi Kalari, Karthik Gaurishetti, Mydhili Radhakrishnan, Yedia Poornachandra, Ramars Amanchy, Sumana Chakravarty, Andugulapati Sai Balaji, Haridas B. Rode

Bioorganic Chemistry, 2023, 106698.

Synthesis and Bio‐evaluation of GR135486X Derivatives as Potent Anti‐Tubercular Agents

Komal G Sangu, Saiprasad Dasugari varakala, Eruva Vamshi Krishna, Abdul Akhir, Deepanshi Saxena, Mohammad Naiyaz Ahmad, Sidharth Chopra, Sunil Misra, Dharmarajan Sriram, Haridas B Rode

ChemistrySelect, 2023, 8 (1), e202204186.

Synthesis and evaluation of novel almazole D analogs as anticancer agents

Abimbola P. Oluyori, Tirunagari Harini, Komal G. Sangu, Eruva Vamshi Krishna, Surender S. Jadav, Sunil Misra, Haridas B. Rode

Archiv der Pharmazie, 2022, 355 (11), 2200102.

Pyrvinium pamoate potentiates levofloxacin against levofloxacin-resistant Staphylococcus aureus

Grace Kaul, Uttam B Karale, Abdul Akhir, Manjulika Shukla, Deepanshi Saxena, Haridas B Rode, Sidharth Chopra

Future Microbiology, 2022, 17 (18), 1475-1486.

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Nitazoxanide potentiates linezolid against linezolid-resistant Staphylococcus aureus in vitro and in vivo

Grace Kaul, Abdul Akhir, Manjulika Shukla, Kundan S Rawat, Chandra P Sharma, Komal G Sangu, Haridas B Rode, Atul Goel, Sidharth Chopra

Journal of Antimicrobial Chemotherapy, 2022, 77 (9), 2456-2460.

Polymer supported cross-linked enzyme aggregates (CLEAs) of lipase B from Candida antarctica: An efficient and recyclable biocatalyst for reactions in both aqueous and organic media

Tirunagari Harini, Jayashree Muddagoni, Gurrala Sheelu, Haridas B Rode, Thenkrishnan Kumaraguru

Biocatalysis and Biotransformation, 2022, 40 (3), 182-194.

Mycobacterium tuberculosis biofilm inhibitors

Abimbola P Oluyori, Haridas B Rode

Future Medicinal Chemistry, 2022, 14 (4), 203-205.

Selectfluor-Mediated Synthesis of β-Acyl Allyl Sulfones/β-Acyl Allyl Benzotriazoles from Ketones/Acetylenes, Aryl Sulfinates/Benzotriazole, and DMSO as a Dual-Carbon Synthon

Saradhi Kalari, Uttam B Karale, Haridas B Rode

The Journal of Organic Chemistry, 2022, 87 (5), 2435-2445.

Methylene-Tethered Arylsulfonation and Benzotriazolation of Aryl/Heteroaryl C–H Bonds with DMSO as a One-Carbon Surrogate

S Kalari, AU Shinde, HB Rode

The Journal of Organic Chemistry, 2021, 86 (24), 17684-17695.

Catalyst-and Additive-Free Approach to Constructing Benzo-oxazine, Benzo-oxazepine, and Benzo-oxazocine: O Atom Transfer and C═ O, C–N, and C–O Bond Formation at Room Temperature

Arnab Ghosh, Rajeev V Hegde, Haridas B Rode, Ram Ambre, Manoj V Mane, Siddappa A Patil, Balasubramanian Sridhar, Ramesh B Dateer

Organic Letters, 2021, 23 (21), 8189-8193.

3‐Aryl‐substituted imidazo[1,2‐a]pyridines as antituberculosis agents

Uttam B Karale, Akash U Shinde, Dattatraya A Babar, Komal G Sangu, Siva Krishna Vagolu, Vamshi K Eruva, Surender S Jadav, Sunil Misra, Sriram Dharmarajan, Haridas B Rode

Archiv der Pharmazie, 2021, 354 (10), 2000419.

Difluorinative-hydroxylation and C-3 functionalization (halogenation/SCN/NO) of imidazopyridine using Selectfluor as fluorine source or oxidant respectively

Saradhi Kalari, Sridhar Balasubramanian, Haridas B Rode

Tetrahedron Letters, 2021, 71, 153028.

Evading antimicrobial resistance using boron-containing therapeutics

Komal G Sangu, Akash U Shinde, Sidharth Chopra, Haridas B Rode

Future Medicinal Chemistry, 2021, 13 (03), 229-232.

Synthesis of novel 4,5‐dihydropyrrolo[1,2‐a]quinoxalines, pyrrolo[1,2‐a]quinoxalin]‐2‐ones and their antituberculosis and anticancer activity

Vitthal B Makane, Eruva Vamshi Krishna, Uattam B Karale, Dattatraya A Babar, Saradhi Kalari, Estharla M Rekha, Manjulika Shukla, Grace Kaul, Dharmarajan Sriram, Sidharth Chopra, Sunil Misra, Haridas B Rode

Archiv der Pharmazie, 2020, 353 (12), 2000192

Synthesis and efficacy of pyrvinium-inspired analogs against tuberculosis and malaria pathogens

Vikas R Gaikwad, Uttam B Karale, Gokulapriya Govindarajalu, Navin Adhikari, E Vamshi Krishna, Vagolu Siva Krishna, Sunil Misra, Dharmarajan Sriram, Puran Sigh Sijwali, Haridas B Rode

Bioorganic & Medicinal Chemistry Letters, 2020, 30 (8), 127037.

Cobalt‐Catalyzed Direct Arylation of Imidazo[1,2‐a]pyridine with Aryl Iodides

DA Babar, HB Rode

European Journal of Organic Chemistry, 2020, 2020 (12), 1823-1827.

Catalyst‐Free Regioselective [3+2] Cycloadditions of α, β‐unsaturated N‐arylnitrones with Alkenes to Access Functionalized Isoxazolidines: A DFT Study

A Ghosh, MV Mane, HB Rode, SA Patil, B Sridhar, RB Dateer

Chemistry–An Asian Journal, 2020, 15 (6), 899-903.

Synthesis and biological evaluation of 2, 4, 5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis

Uttam B Karale, Vagolu Siva Krishna, E Vamshi Krishna, Amit S Choudhari, Manjulika Shukla, Vikas R Gaikwad, B Mahizhaveni, Sidharth Chopra, Sunil Misra, Dhiman Sarkar, Dharmarajan Sriram, VN Azger Dusthackeer, Haridas B Rode

European Journal of Medicinal Chemistry, 2019, 178, 315-328.

Novel 1, 3, 4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis

Vitthal B Makane, Vagolu Siva Krishna, Eruva Vamshi Krishna, Manjulika Shukla, Balakrishnan Mahizhaveni, Sunil Misra, Sidharth Chopra, Dharmarajan Sriram, Vijayan N Azger Dusthackeer, Haridas B Rode

Future Medicinal Chemistry, 2019, 11 (6), 499-510.

Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis

Vitthal B Makane, Vagolu Siva Krishna, E Vamshi Krishna, Manjulika Shukla, B Mahizhaveni, Sunil Misra, Sidharth Chopra, Dharmarajan Sriram, VN Azger Dusthackeer, Haridas B Rode

European Journal of Medicinal Chemistry, 2019, 164, 665-677.

Strategies towards the synthesis of anti-tuberculosis drugs

Haridas B Rode, Dhanaji M Lade, René Grée, Prathama S Mainkar, Srivari Chandrasekhar

Organic & Biomolecular Chemistry, 2019, 17 (22), 5428-5459.

Transition metal-free functionalized hydration of alkynes: one-pot synthesis of fluorinated β-keto-imidates using Selectfluor

A Ghosh, R Hegde, VB Makane, B Sridhar, HB Rode, SA Patil, RB Dateer

Organic & Biomolecular Chemistry, 2019, 17 (18), 4440-4445.

Crosslinked enzyme aggregates (CLEA) of phytase with soymilk proteins

Harini Tirunagari, Shalini Basetty, Haridas B Rode, Nitin W Fadnavis

Journal of Biotechnology, 2018, 282, 67-69.

Palladium (II) Acetate/Base‐Catalyzed Intermolecular Coupling of Imidazo[1, 2‐a]pyridine Esters with Aryl Halides

Dattatraya A Babar, Saradhi Kalari, Uttam B Karale, Vitthal B Makane, Haridas B Rode

ChemistrySelect, 2018, 8 (1), e202204186.

Studies towards the synthesis of trocheliophorolides

Haridas B. Rode Navnath B. Khomane, Harshadas M. Meshram

Tetrahedron Letters, 2018, 59 (22), 2157-2160.

On water direct arylation of imidazo [1, 2-a] pyridines with aryl halides

Saradhi Kalari, Dattatraya A Babar, Uttam B Karale, Vitthal B Makane, Haridas B Rode

Tetrahedron Letters, 2017, 58 (29), 2818-2821.

A Facile synthesis and antituberculosis properties of almazole D and its enantiomer

Dhanaji M Lade, Vagolu Siva Krishna, Dharmarajan Sriram, Haridas B Rode

ChemistrySelect, 2017, 2 (3), 1250-1252.

Ligand-free Pd-catalysed decarboxylative arylation of imidazo [1, 2-a] pyridine-3-carboxylic acids with aryl bromides

Uttam B Karale, Saradhi Kalari, Jala Shivakumar, Vitthal B Makane, Dattatraya A Babar, Ritesh P Thakare, Bathini Nagendra Babu, Sidharth Chopra, Haridas B Rode

RSC Advances, 2016, 6 (69), 65095-65104.

Identification of new molecular entities (NMEs) as potential leads against tuberculosis from open source compound repository

Sudha Sravanti Kotapalli, Sri Satya Anila Nallam, Lavanya Nadella, Tanmay Banerjee, Haridas B Rode, Prathama S Mainkar, Ramesh Ummanni

PLoS One, 2015, 10 (12), e0144018.

Methyl 3-[(1,1-dioxo-16,2-benzothiazol-3-yl)amino]-5-nitrothiophene-2-carboxylate

H. B. Rode, J. Chojnacki and H.-H. Otto

Acta Crystallographica Section E: Structure Reports Online, 2012, 68 (10), o2951-o2952.

A Chemical Genetic Approach for Covalent Inhibition of Analogue-Sensitive Aurora Kinase

André Koch, Haridas B Rode, André Richters, Daniel Rauh, Silke Hauf

ACS Chemical Biology, 2012, 7 (4), 723-731.

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor

Haridas B Rode, Martin L Sos, Christian Grütter, Stefanie Heynck, Jeffrey R Simard, Daniel Rauh

Bioorganic & Medicinal Chemistry, 2011, 19 (1), 429-439.

Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010)

Sabine Klüter, Jeffrey R Simard, Haridas B Rode, Christian Grütter, Vijaykumar Pawar, Hans CA Raaijmakers, Tjeerd A Barf, Matthias Rabiller, Willem AL van Otterlo, Daniel Rauh

ChemBioChem, 2010, 11 (18), 2474-2474.

Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance

Sabine Klüter, Jeffrey R Simard, Haridas B Rode, Christian Grütter, Vijaykumar Pawar, Hans CA Raaijmakers, Tjeerd A Barf, Matthias Rabiller, Willem AL van Otterlo, Daniel Rauh

ChemBioChem, 2010, 11 (18), 2557-2566.

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor

Vijaykumar G Pawar, Martin L Sos, Haridas B Rode, Matthias Rabiller, Stefanie Heynck, Willem AL Van Otterlo, Roman K Thomas, Daniel Rauh

Journal of Medicinal Chemistry, 2010, 53 (7), 2892-2901.

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation

Martin L Sos, Haridas B Rode, Stefanie Heynck, Martin Peifer, Florian Fischer, Sabine Klüter, Vijaykumar G Pawar, Cecile Reuter, Johannes M Heuckmann, Jonathan Weiss, Lars Ruddigkeit, Matthias Rabiller, Mirjam Koker, Jeffrey R Simard, Matthäus Getlik, Yuki Yuza, Tzu-Hsiu Chen, Heidi Greulich, Roman K Thomas, Daniel Rauh

Cancer Research, 2010, 70 (3), 868-874.

Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling

Martin Peifer, Jonathan Weiss, Martin L Sos, Mirjam Koker, Stefanie Heynck, Christian Netzer, Stefanie Fischer, Haridas Rode, Daniel Rauh, Jörg Rahnenführer, Roman K Thomas

PloS One, 2010, 5 (1), e8919.

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc

Matthäus Getlik, Christian Grütter, Jeffrey R Simard, Sabine Klüter, Matthias Rabiller, Haridas B Rode, Armin Robubi, Daniel Rauh

Journal of Medicinal Chemistry, 2009, 52 (13), 3915-3926.

A new screening assay for allosteric inhibitors of cSrc

Jeffrey R Simard, Sabine Klüter, Christian Grütter, Matthäus Getlik, Matthias Rabiller, Haridas B Rode, Daniel Rauh

Nature Chemical Biology, 2009, 5 (6), 394-396.

Fluorescent-tagged Kinases: A New Assay System For Detecting And Screening For Allosteric Kinase Inhibitors

Jeffrey R Simard, Matthäus Getlik, Sabine Klüter, Christian Grütter, Matthias Rabiller, Sabine Wulfert, Lars Ruddigkeit, Vijaykumar Pawar, Haridas B Rode, Daniel Rauh

Biophysical Journal, 2009, 96 (3), 597a-598a.

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR

Anja Michalczyk, Sabine Klueter, Haridas B Rode, Jeffrey R Simard, Christian Gruetter, Matthias Rabiller, Daniel Rauh

Bioorganic & Medicinal Chemistry, 2008, 16 (7), 3482-3488.

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

Jimmy A Blair, Daniel Rauh, Charles Kung, Cai-Hong Yun, Qi-Wen Fan, Haridas Rode, Chao Zhang, Michael J Eck, William A Weiss, Kevan M Shokat

Nature Chemical Biology, 2007, 3 (4), 229-238.

Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors

Haridas Rode, Stefanie Koerbe, Anita Besch, Karen Methling, Jutta Loose, Hans-Hartwig Otto

Bioorganic & Medicinal Chemistry, 2006, 14 (8), 2789-2798.

Pseudosaccharin amine derivatives: synthesis and elastase inhibitory activity

HB Rode, T Sprang, A Besch, J Loose, H-H Otto

Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2005, 60(10), 723-731.